I’ve been rolling for quite some time with Flash disabled in Chrome for performance reasons (battery life on my laptop) and security (flash cookies), however there’s a difference from surfing the web with Safari/FireFox without Flash and Chrome and it looks like this:

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Sadly this isn’t limited to FaceBook, if you’re designing to the browser, you’re doing it wrong. In the day of age of feature detection and progressive enhancement design patterns, this shouldn’t be a problem.